Adaptive deep brain stimulation in Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Adaptive deep brain stimulation in Parkinson's disease
Although Deep Brain Stimulation (DBS) is an established treatment for Parkinson's disease (PD), there are still limitations in terms of effectivity, side-effects and battery consumption. One of the reasons for this may be that not only pathological but also physiological neural activity can be suppressed whilst stimulating. For this reason, adaptive DBS (aDBS), where stimulation is applied acco...
متن کاملDeep Brain Stimulation of the Subthalamic Nucleus Improves Lexical Switching in Parkinsons Disease Patients
OBJECTIVE Reduced verbal fluency (VF) has been reported in patients with Parkinson's disease (PD), especially those treated by Deep Brain Stimulation of the subthalamic nucleus (STN DBS). To delineate the nature of this dysfunction we aimed at identifying the particular VF-related operations modified by STN DBS. METHOD Eleven PD patients performed VF tasks in their STN DBS ON and OFF conditio...
متن کاملAdaptive Deep Brain Stimulation In Advanced Parkinson Disease
OBJECTIVE Brain-computer interfaces (BCIs) could potentially be used to interact with pathological brain signals to intervene and ameliorate their effects in disease states. Here, we provide proof-of-principle of this approach by using a BCI to interpret pathological brain activity in patients with advanced Parkinson disease (PD) and to use this feedback to control when therapeutic deep brain s...
متن کاملFirst steps towards adaptive deep brain stimulation in Parkinson’s disease
Introduction: Deep brain stimulation (DBS) is used to treat Parkinson's disease (PD), when medical therapies are not efficient enough [1]. DBS requires the implantation of stimulation electrodes reaching into deep brain areas, commonly into the subthalamic nucleus (STN) that is one of the relay of the extrapyramidal circuit. Electrical pulses are sent on a fixed regular pace. Despite the proven...
متن کاملBilateral adaptive deep brain stimulation is effective in Parkinson's disease
INTRODUCTION & OBJECTIVES Adaptive deep brain stimulation (aDBS) uses feedback from brain signals to guide stimulation. A recent acute trial of unilateral aDBS showed that aDBS can lead to substantial improvements in contralateral hemibody Unified Parkinson's Disease Rating Scale (UPDRS) motor scores and may be superior to conventional continuous DBS in Parkinson's disease (PD). We test whether...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Parkinsonism & Related Disorders
سال: 2016
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2015.09.028